Development and Demonstration of Measurement-Time Efficient Methods for Impedance Spectroscopy of Electrode and Sensor Arrays

The development of impedance-based array devices is hindered by a lack ofrobust platforms and methods upon which to evaluate and interrogate sensors. One aspectto be addressed is the development of measurement-time efficient techniques forbroadband impedance spectroscopy of large electrode arrays. The objective of this workwas to substantially increase the low frequency impedance measurement throughputcapability of a large channel count array analyzer by developing true parallel measurementmethods. The goal was achieved by Fourier transform-based analysis of simultaneouslyacquiredmulti-channel time-based current and voltage data. Efficacy and quantitativeanalysis of the parallel approach at frequencies less than ca. 10 Hz as well as a combinedsequential parallel approach for efficient broadband impedance spectroscopy over 5-orders of magnitude in frequency is demonstrated through complex impedancemeasurement of arrays consisting of up to 100 elements.